Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Nitrophenyl (NP)-specific helper cells and suppressor cells were induced in vitro using NP-T4 bacteriophage as antigen. These cells could mediate their effects also by secreted effector molecules, helper and suppressor factors. The function of both NP-specific helper and suppressor cells was abolished by treatment with anti-Thy1.2 plus C', but they were not retained on nylon wool columns, suggesting that NP-specific helpers and suppressors were T cells. The membrane phenotype of both NP-specific helper and suppressor cells was found to be Ly1+2+I-J+(I-A-). The secreted effector molecules, helper and suppressor factors which mediate helper or suppressor function, bound to NP immunoadsorbents and are NP-specific in their function. They do not have conventional Ig determinants, but both bear determinants coded by the I-J subregion of H-2. The unusual phenotype of NP-specific helper and suppressor cells is discussed, as is the potential use of these hapten-specific T cells and their secreted effector molecules in increasing our understanding of T-cell receptors, effector molecules and the fine specificity of the interacting network in the regulation of immune responses.


Journal article


Ann Immunol (Paris)

Publication Date





239 - 255


Animals, Cells, Cultured, Epitopes, Haptens, Mice, Mice, Inbred Strains, Nitrophenols, Phenylacetates, Spleen, T-Lymphocytes, T-Lymphocytes, Regulatory, T-Phages