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T cell activation requires interactions of T cell antigen receptors and peptides presented by major histocompatibility complex molecules in an adhesive junction between the T cell and antigen-presenting cell (APC). Stable junctions with bull's-eye supramolecular activation clusters have been defined as immunological synapses (IS). These structures maintain T cell-APC interaction and allow directed secretion. T cells can also be activated by asymmetric hemisynapses (HS) that allow migration during signal integration. IS and HS dominate in different stages of T cell priming. Optimal effector functions may also depend upon cyclical use of IS and HS.


Journal article


Results Probl Cell Differ

Publication Date





175 - 198


Animals, Antigen-Presenting Cells, Autoimmunity, Cell Movement, Humans, Intercellular Junctions, Lymphocyte Activation, Models, Immunological, Receptors, Antigen, T-Cell, Signal Transduction, T-Lymphocytes