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The stable immunological synapse between a T cell and antigen-presenting cell coordinates migration and activation. Three-dimensional collagen gels transform this interaction into a series of transient hit-and-run encounters. Here we integrate these alternative modes of interaction in a model for primary T cell activation and effector function in vivo.


Journal article


Curr Opin Immunol

Publication Date





286 - 290


Animals, Cell Movement, Extracellular Matrix, Humans, Lymphocyte Activation, Organ Specificity, T-Lymphocytes