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The development of safe and effective vaccines for cancer and infectious diseases remains a major goal in public health. Over the last two decades, controlled release of vaccine antigens and immunostimulant molecules has been achieved using nanometer or micron-sized delivery vehicles synthesized using biodegradable polymers. In addition to achieving a depot effect, enhanced vaccine efficacy using such delivery vehicles has been attributed to efficient targeting of antigen presenting cells such as dendritic cells. Biodegradable and biocompatible poly(lactic acid) and poly(lactic-co-glycolic acid) polymers belong to one such family of polymers that have been a popular choice of material used in the design of these delivery vehicles. This review summarizes research findings from ourselves and others highlighting the promise of poly(lactic acid)- and poly(lactic-co-glycolic acid)-based vaccine carriers in enhancing immune responses.

Original publication




Journal article


Nanomedicine (Lond)

Publication Date





2703 - 2718


PLA, PLGA, adjuvants, biodegradable, controlled release, immune response, particles, vaccine delivery, Adjuvants, Immunologic, Antigens, Dendritic Cells, Drug Carriers, Drug Delivery Systems, Humans, Immunity, Cellular, Lactic Acid, Microspheres, Polyesters, Polyglycolic Acid, Polylactic Acid-Polyglycolic Acid Copolymer, Polymers, Vaccines