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: The impact of antiretroviral therapy (ART) on the size of the HIV reservoir has implications for virological remission in adults, but is not well characterized in perinatally acquired infection. In a prospective observational study of 20 children with perinatally acquired infection and sustained viral suppression on ART for more than 5 years, proviral DNA was significantly higher in deferred (>4 years) versus early (first year of life) ART recipients (P = 0.0062), and correlated with age of initiation (P = 0.13; r = 0.57). No difference was seen in cell-associated viral RNA (P = 0.36). Identifying paediatric populations with smaller reservoirs may inform strategies with potential to induce ART-free remission.

Original publication

DOI

10.1097/qad.0000000000001565

Type

Journal article

Journal

AIDS (London, England)

Publication Date

08/2017

Volume

31

Pages

1847 - 1851

Addresses

aDivision of Medicine, Wright Fleming Institute, Imperial College, London bNuffield Department of Clinical Medicine, John Radcliffe Hospital, Peter Medawar Building for Pathogen Research, Oxford cKing's College London Infectious Diseases BioBank, London dInstitute for Emerging Infections, The Oxford Martin School eOxford National Institute of Health Research Biomedical Research Centre, Oxford, UK. *Caroline Foster, Sarah Fidler, and John Frater contributed equally to this article.

Keywords

CHERUB Investigators