Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

: The impact of antiretroviral therapy (ART) on the size of the HIV reservoir has implications for virological remission in adults, but is not well characterized in perinatally acquired infection. In a prospective observational study of 20 children with perinatally acquired infection and sustained viral suppression on ART for more than 5 years, proviral DNA was significantly higher in deferred (>4 years) versus early (first year of life) ART recipients (P = 0.0062), and correlated with age of initiation (P = 0.13; r = 0.57). No difference was seen in cell-associated viral RNA (P = 0.36). Identifying paediatric populations with smaller reservoirs may inform strategies with potential to induce ART-free remission.

Original publication




Journal article


AIDS (London, England)

Publication Date





1847 - 1851


aDivision of Medicine, Wright Fleming Institute, Imperial College, London bNuffield Department of Clinical Medicine, John Radcliffe Hospital, Peter Medawar Building for Pathogen Research, Oxford cKing's College London Infectious Diseases BioBank, London dInstitute for Emerging Infections, The Oxford Martin School eOxford National Institute of Health Research Biomedical Research Centre, Oxford, UK. *Caroline Foster, Sarah Fidler, and John Frater contributed equally to this article.


CHERUB Investigators