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Eliminating hematopoietic stem cells (HSCs) with DNA damage is necessary to maintain the homeostasis of HSCs, but the mechanisms underlying this apoptotic elimination are unclear. Now in Cell Stem Cell, Yamashita et al. (2015) show that Aspp1 coordinates with p53 to protect HSC pool integrity, guarding against hematological malignancies.

Original publication

DOI

10.1016/j.stem.2015.06.012

Type

Journal article

Journal

Cell Stem Cell

Publication Date

02/07/2015

Volume

17

Pages

3 - 5

Keywords

Adaptor Proteins, Signal Transducing, Animals, Cell Transformation, Neoplastic, Hematopoietic Stem Cells