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Macrophages are a highly plastic cell type and exhibit a range of defensive and regulatory functions in normal physiology. Phagocytic macrophages play an important role in defending against virus infection and they provide an important barrier that can limit the delivery of therapeutic viruses from the injection to the tumour. Within tumours, macrophages generally adopt an immunosuppressive phenotype and are associated with poor clinical prognosis. However their plasticity also provides the opportunity for therapeutic 're-education' of tumour-associated macrophages (TAMs) to adopt an active anticancer role. Oncolytic viruses present the possibility for non-specific stimulation of TAMs, and also the option for tumour-targeted expression of cytokines chosen specifically to modulate macrophage activation.

Original publication

DOI

10.1016/j.coph.2015.06.007

Type

Journal article

Journal

Curr Opin Pharmacol

Publication Date

10/2015

Volume

24

Pages

23 - 29

Keywords

Humans, Macrophages, Oncolytic Viruses