Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

We have demonstrated that the relative contribution of secreted and membrane-associated proteins to the cytotoxicity of LAK cells depended on LAK cell phenotype: the cytotoxicity of CD16+ CD8+ CD3- LAK cells was associated mainly with membrane-bound proteins, and the activity of CD3+ CD8+ CD16- LAK cells was due mainly to secreted soluble proteins. The cytotoxic activity of membrane fractions of LAK cells against cell line L929 was determined by 40-, 32- and 21-kDa proteins for LAK cells bearing NK-specific markers and due to proteins of 34 and 21 kDa in the case of 'CTL-like' LAK-cells.

Type

Journal article

Journal

Immunol Lett

Publication Date

03/1994

Volume

39

Pages

243 - 247

Keywords

Animals, Cytotoxins, Electrophoresis, Polyacrylamide Gel, Humans, Immunoblotting, Immunophenotyping, Killer Cells, Lymphokine-Activated, L Cells (Cell Line), Membrane Proteins, Mice, Tumor Cells, Cultured