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We have demonstrated that the relative contribution of secreted and membrane-associated proteins to the cytotoxicity of LAK cells depended on LAK cell phenotype: the cytotoxicity of CD16+ CD8+ CD3- LAK cells was associated mainly with membrane-bound proteins, and the activity of CD3+ CD8+ CD16- LAK cells was due mainly to secreted soluble proteins. The cytotoxic activity of membrane fractions of LAK cells against cell line L929 was determined by 40-, 32- and 21-kDa proteins for LAK cells bearing NK-specific markers and due to proteins of 34 and 21 kDa in the case of 'CTL-like' LAK-cells.


Journal article


Immunol Lett

Publication Date





243 - 247


Animals, Cytotoxins, Electrophoresis, Polyacrylamide Gel, Humans, Immunoblotting, Immunophenotyping, Killer Cells, Lymphokine-Activated, L Cells (Cell Line), Membrane Proteins, Mice, Tumor Cells, Cultured