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A protein-inhibiting LAK cell-mediated cytotoxicity was isolated from a LAK cell-conditioned medium. The N-terminal amino acid sequence of this protein appeared to be identical to fetal calf fetuin. Pure isolated fetuin, as well as commercially available preparations of this protein, were shown to inhibit cytotoxic activity of both cytotoxic proteins released by LAK cells and TNF.

Type

Journal article

Journal

Immunol Lett

Publication Date

09/1994

Volume

42

Pages

97 - 100

Keywords

Animals, Cattle, Culture Media, Conditioned, Cytotoxicity, Immunologic, Fibroblasts, Humans, Killer Cells, Lymphokine-Activated, Mice, Recombinant Proteins, Tumor Cells, Cultured, Tumor Necrosis Factor-alpha, alpha-Fetoproteins