Inhibitory effect of calf fetuin on the cytotoxic activity of LAK cell-derived factors and tumor necrosis factor.
Chertov OYu None., Ermolaeva MV., Satpaev DK., Saschenko LP., Kabanova OD., Lukanidin EM., Lukjianova TI., Redchenko IV., Blishchenko LYu None., Gnuchev NV.
A protein-inhibiting LAK cell-mediated cytotoxicity was isolated from a LAK cell-conditioned medium. The N-terminal amino acid sequence of this protein appeared to be identical to fetal calf fetuin. Pure isolated fetuin, as well as commercially available preparations of this protein, were shown to inhibit cytotoxic activity of both cytotoxic proteins released by LAK cells and TNF.