CISH and susceptibility to infectious diseases.
Khor CC., Vannberg FO., Chapman SJ., Guo H., Wong SH., Walley AJ., Vukcevic D., Rautanen A., Mills TC., Chang K-C., Kam K-M., Crampin AC., Ngwira B., Leung C-C., Tam C-M., Chan C-Y., Sung JJY., Yew W-W., Toh K-Y., Tay SKH., Kwiatkowski D., Lienhardt C., Hien T-T., Day NP., Peshu N., Marsh K., Maitland K., Scott JA., Williams TN., Berkley JA., Floyd S., Tang NLS., Fine PEM., Goh DLM., Hill AVS.
The interleukin-2-mediated immune response is critical for host defense against infectious pathogens. Cytokine-inducible SRC homology 2 (SH2) domain protein (CISH), a suppressor of cytokine signaling, controls interleukin-2 signaling.