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A defining feature of Trypanosoma brucei cell shape is the lateral attachment of the flagellum to the cell body, mediated by the flagellum attachment zone (FAZ). The FAZ is a complex cytoskeletal structure that connects the flagellum skeleton through two membranes to the cytoskeleton. The FAZ acts as a 'cellular ruler' of morphology by regulating cell length and organelle position and is therefore critical for both cell division and life cycle differentiations. Here we provide an overview of the advances in our understanding of the composition, assembly, and function of the FAZ.

Original publication

DOI

10.1016/j.pt.2015.12.010

Type

Journal article

Journal

Trends in parasitology

Publication Date

04/2016

Volume

32

Pages

309 - 324

Addresses

Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK. Electronic address: jack.sunter@path.ox.ac.uk.

Keywords

Flagella, Trypanosoma brucei brucei, RNA Interference, Protein Transport, Morphogenesis