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Tlymphocytes of the immune system need to integrate myriad signals to decide on life and death matters in defending the host from pathogens and in distinguishing normal from transformed cells, all while minimizing immunopathology. On page 595 in this issue, Su et al. (1) provide insight into how phase separation of signaling proteins in the two-dimensional (2D) liquid of the plasma membrane enables these critical decisions.

Type

Journal article

Journal

Science (New York, N.Y.)

Publication Date

04/2016

Volume

352

Pages

516 - 517

Keywords

T-Lymphocytes, Humans, Actins, Adaptor Proteins, Signal Transducing, Membrane Proteins, Receptors, Antigen, T-Cell