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IL-33 is the most recent addition to the IL-1 cytokine family, identified in 2005 as the ligand of T1/ST2 and inducer of type-2 immune responses. IL-33 has been implicated in a wide range of disease settings, in anti-inflammatory responses and homeostasis, and thus signalling must be strictly regulated. Altered gene expression, post-translational modification, decoy receptor, and receptor signalling are all modulatory mechanisms used to control the IL-33 pathway. Understanding both the genetic and post-translational factors influencing IL-33 activity will be critical for provision of safe effective treatment of type-2 disorders.

Original publication




Journal article


Curr Opin Immunol

Publication Date





16 - 24


Animals, Anti-Inflammatory Agents, Gene Expression Regulation, Homeostasis, Humans, Immunity, Cellular, Interleukin-1 Receptor-Like 1 Protein, Interleukin-33, Protein Processing, Post-Translational, Signal Transduction, Th2 Cells, Wound Healing