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Linkage analysis of type 1 diabetes sib pair families (n = 334) has suggested two separate regions of human chromosome 6q are linked to disease (designated IDDM5 and IDDM8). To test if these are false positive results, all available sib pair families (n = 429) were typed using a 92% informative map of chromosome 6q and multipoint analysis. The two regions still showed positive evidence of linkage, most notably the proterminal region, 6q27, corresponding to IDDM8 (MLS = 2.57, p = 0.0006; lambda s = 1.17). In addition, some evidence of transmission disequilibrium was seen with marker a046xa9 (IDDM5).

Original publication

DOI

10.1093/hmg/5.7.1071

Type

Journal article

Journal

Hum Mol Genet

Publication Date

07/1996

Volume

5

Pages

1071 - 1074

Keywords

Chromosome Mapping, Chromosomes, Human, Pair 6, Diabetes Mellitus, Type 1, Epistasis, Genetic, Genetic Linkage, Genetic Markers, Humans, Matched-Pair Analysis, Nuclear Family