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Development of novel congenic mouse strains has allowed us to better define the location of the diabetogenic locus, Idd3, on Chromosome (Chr) 3. Congenic strains were identified by use of published and newly developed microsatellite markers, their genomes fingerprinted by a rapid, fluorescence-based approach, and their susceptibility to type 1 diabetes evaluated. The maximum interval containing Idd3 is now approximately 4 cM.

Type

Journal article

Journal

Mamm Genome

Publication Date

09/1995

Volume

6

Pages

563 - 570

Keywords

Animals, Base Sequence, Chromosome Mapping, DNA Primers, Diabetes Mellitus, Type 1, Female, Humans, Male, Mice, Mice, Inbred C57BL, Mice, Inbred NOD, Molecular Sequence Data, Polymerase Chain Reaction