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Populations of humans and mice contain alleles at many loci that protect from immune-mediated diseases. Identification of these alleles, some which are likely to function in immune recognition, tolerance, and regulation, will facilitate the development of diagnostics as well as therapeutics that alter disease progression.

Type

Journal article

Journal

Immunity

Publication Date

09/2001

Volume

15

Pages

387 - 395

Keywords

Alleles, Animals, Chromosome Mapping, Diabetes Mellitus, Type 1, Disease Models, Animal, Genes, MHC Class II, HLA-DQ Antigens, Humans, Insulin, Multigene Family, Proinsulin, Protein Precursors