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The recent discovery of tumour necrosis factor has been a major advance in the understanding of the biology of the immunological system. A review of this macrophage-secreted polypeptide hormone may be of special interest to clinicians because it appears to play a role in several important disease processes and holds considerable promise as a therapeutic tool.


Journal article


S Afr Med J

Publication Date





411 - 417


Animals, Humans, Mice, Tumor Necrosis Factor-alpha