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Dengue (DENV), West Nile (WNV) and Zika (ZIKV) viruses are mosquito-transmitted flaviviruses that cause thousands of human deaths and millions of illnesses each year. In the last decades, epidemic outbreaks of all three flaviviruses emerged and caused a major health and economical problem in many parts of the world. The increasing and expanding burden of flaviviruses has highlighted the need for effective human vaccines against all three viruses. This review provides an overview of the recent progress in DENV, WNV and ZIKV vaccines development with specific focus on candidates in human clinical development.

Original publication

DOI

10.1016/j.coviro.2017.04.002

Type

Journal article

Journal

Curr Opin Virol

Publication Date

04/2017

Volume

23

Pages

95 - 101

Keywords

Dengue, Dengue Virus, Drug Discovery, Humans, Viral Vaccines, West Nile Fever, West Nile virus, Zika Virus, Zika Virus Infection