Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

The blood vasculature provides both oxygen and nutrients to the high energetic environment of lymphoid tissue and provides a portal for entry of lymphocytes. The vasculature is uniquely different from that found in other organs due to the requirement for efficient recruitment of lymphocytes under non-inflammatory, physiological conditions. It is highly spatially organised, controlling both the site of cellular entry and contributing to the structural organisation of lymphoid tissues. Understanding the mechanisms of blood vasculature development and function is central to understanding how lymphoid tissues form and to understanding mechanisms regulating adaptive immune responses and disease pathologies. Here, we review the development, maintenance and plasticity of lymphoid blood vasculature, as well as the tissue-specific expression patterns of high endothelial venules, which govern lymphocyte trafficking in steady state and during inflammation. © Springer-Verlag Berlin Heidelberg 2011.

Original publication





Book title

Developmental Biology of Peripheral Lymphoid Organs

Publication Date



75 - 94