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© 2016 Elsevier Ltd All rights reserved. Transplantation has revolutionized the treatment of organ failure but remains limited by the challenge of controlling alloresponses to the organ transplant. Central to addressing this challenge is understanding the nature of the immune response and developing safer methods for its control. In vivo models are critical to this goal as they facilitate investigation of novel therapies in the context of a complete immune system. This article details the various transplantation animal models and their merits and limitations.

Original publication





Book title

Encyclopedia of Immunobiology

Publication Date





270 - 274