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ASPP2 stimulates the apoptotic function of the p53 family in vivo. We show here that ASPP2-/- pups died before weaning. This postnatal lethality was significantly enhanced in p53+/- background and both deletions are synthetic lethal. ASPP2+/- mice developed spontaneous tumors. The tumor onset was accelerated by gamma-irradiation or in p53+/- background. Tumors derived from ASPP2+/- mice retained wild-type ASPP2 allele even though some of them lost p53. These provide the first genetic evidence that ASPP2 is a haploinsufficient tumor suppressor that shares overlapping function(s) with p53 in mouse development and tumor suppression.

Original publication

DOI

10.1101/gad.374006

Type

Journal article

Journal

Genes Dev

Publication Date

15/05/2006

Volume

20

Pages

1262 - 1267

Keywords

Alleles, Animals, Genes, Lethal, Genes, Tumor Suppressor, Haploidy, Heterozygote, Lymphoma, Mice, Mice, Mutant Strains, Mutation, Tumor Suppressor Protein p53, Tumor Suppressor Proteins