Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

All viruses infecting ticks (with one possible exception) are arboviruses; their life cycle depends on infection and replication in both tick and vertebrate host cells. Little is known of arbovirus-tick cell interactions even though tick-borne viruses spend most of their existence in ticks. A distinct selection pressure on tick-borne viruses is the intracellular process of bloodmeal digestion in ticks (contrasting with insects) This may explain the pronounced differences in surface structure of tick-borne and insect-borne orbiviruses. Some indications of molecular interactions can be extrapolated from vertebrate cells, such as utilisation of aggresome pathways. Although many (if not all) tick-borne viruses exploit the immunomodulatory effects of tick saliva on the vertebrate host, there is no evidence they interact directly with saliva molecules. However, the most fundamental question to address is the benign infection of arboviruses in tick cells compared with their cytopathic effect in vertebrate cells. As the tick proteome is unravelled, its interaction with the viral proteome should help explain the interactions between ticks and the many important viruses they transmit.

Type

Journal article

Journal

Front Biosci (Landmark Ed)

Publication Date

01/01/2009

Volume

14

Pages

2466 - 2483

Keywords

Animals, Arachnid Vectors, Host-Parasite Interactions, Tick-Borne Diseases, Ticks, Virus Physiological Phenomena, Viruses