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In a previous study (Hajnicka, V. et al., Parasitology 116, 533-538, 1998), the infectivity titer of vesicular stomatitis virus (VSV) was shown to increase up to 10,000-fold when mouse L cells were treated with tick salivary gland extract (SGE) prior to infection. To examine this effect at the level of viral protein production, radiolabeled VSV-infected cells were analyzed by double-dimensional gel electrophoresis. A pre-treatment of cells with SGE from partially fed ticks in amounts corresponding to 1 or 3 salivary glands increased the level of both viral nucleocapsid (N) protein and phosphoprotein (P) in a dose-dependent manner. The effect was more pronounced for N protein and could account for the dramatic increase in infectious virus yield. Promotion of viral infectivity by arthropod saliva may support the arthropode-borne transmission cycle of VSV.


Journal article


Acta Virol

Publication Date





251 - 254


Animals, Arachnid Vectors, Cell Line, Dermacentor, Mice, Nucleocapsid, Nucleocapsid Proteins, Phosphoproteins, Saliva, Salivary Glands, Vesicular stomatitis Indiana virus, Viral Structural Proteins, Virus Replication