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The interferon-induced mouse Mx1 protein has intrinsic antiviral activity against orthomyxoviruses, including Thogoto virus. Thus, Mx1(+) A2G mice are apparently resistant to infection following needle- or tick-borne virus challenge. However, tick-borne challenge and, to a lesser degree, injection of virus mixed with tick salivary gland extract resulted in virus transmission to uninfected ticks feeding on the A2G mice. The data indicate that immunomodulatory components in tick saliva can overcome a natural antiviral mechanism.

Type

Journal article

Journal

J Virol

Publication Date

10/1998

Volume

72

Pages

8362 - 8364

Keywords

Animals, Antiviral Agents, Arachnid Vectors, GTP-Binding Proteins, Mice, Myxovirus Resistance Proteins, Orthomyxoviridae Infections, Proteins, Saliva, Thogotovirus, Ticks