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The sensitivity of Borrelia burgdorferi sensu lato to animal sera was analyzed. Complement-mediated borreliacidal effects were observed with particular combinations of host serum and Borrelia genospecies. The species-specific pattern of viability and/or lysis is highly consistent with the pattern of reservoir competence of hosts for B. burgdorferi sensu lato, suggesting a key role of complement in the global ecology of Lyme borreliosis.

Type

Journal article

Journal

Infect Immun

Publication Date

03/1998

Volume

66

Pages

1248 - 1251

Keywords

Animals, Bacteriolysis, Complement System Proteins, Cricetinae, Ecology, Humans, Lyme Disease, Mesocricetus, Mice, Mice, Inbred BALB C, Muridae, Species Specificity