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Certain immunological responses of 4-6 month old calves experimentally inoculated with either cytopathic or non-cytopathic bovine virus diarrhoea virus (BVDV) were compared with those of uninfected control calves. The tests used to demonstrate the immunological responses were the transformation of lymphocytes by PHA mitogen, the percentage of lymphocytes with surface immunoglobulin, and the antibody titres induced by an intravenous inoculation of killed Brucella abortus. There were no significant differences between the two groups of calves and therefore, the mild experimental disease produced by BVDV did not appear to affect adversely the immunological response.


Journal article


Vet Immunol Immunopathol

Publication Date





371 - 378


Animals, Antibodies, Bacterial, Bovine Virus Diarrhea-Mucosal Disease, Brucella abortus, Cattle, Diarrhea Viruses, Bovine Viral, Immunoglobulins, Lymphocyte Activation, Phytohemagglutinins