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Objective To study the expression and function of murine platelets and T cell activation antigen 1 (PTA1), a novel leukocyte differentiation antigen initially described in human activated T cells and platelets , later in monkey and gibbon cells. Methods By using PTA1-specific McAb LeoAl, flow cytometry analysis of murine cell lines and murine mixed lymphocyte reaction (MLR) were taken. Results Flow cytometry analysis showed that murine PTA1 was expressed mainly in activated T cells, and this expression could be induced by phytohemoagglutinin (PHA) and phorbol ester (PMA). MLR experiment showed that LeoA1 McAb could block the induction of cytotoxic T lymphocytes (CTL) induced by alloantigen, but had no effect on the function of CTL when added at effector phase. LeoA1 had effect on neither the differentiation nor the function of lymphokine-activated killer (LAK) cells. Conclusions PTA1 is a highly conserved leukocyte differentiation antigen during evolution, and murine PTA1 is a novel mouse leukocyte differentiation antigen with the same pattern of expression and function as human PTA1.

Type

Journal article

Journal

Chinese Journal of Microbiology and Immunology

Publication Date

01/05/1999

Volume

19

Pages

232 - 235