Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

A model system has been developed to study the role of segregation in T cell activation. The system involves the formation of an immunological synapse that is quantitatively visualized in real time. Supported planar bilayers were prepared with fluorescently labeled MHC-peptide complexes and adhesion molecules. Molecular segregation of engaged MHC-peptide and ICAM-1 complexes was strongly correlated with T cell proliferation. These data support the hypothesis that molecular segregation is important for T cell signaling.


Conference paper

Publication Date