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A cDNA clone encoding the human T lymphocyte sheep erythrocyte receptor [the CD2 (T11) antigen] was used as a probe to define the chromosomal location of the gene. The signal, revealed by hybridisation to Southern blots of genomic DNA from somatic cell hybrids, showed a high degree of concordance for human chromosome 1. In particular, the hybrid F4Sc13C19 which contained the short arm only of human chromosome 1 was positive. The location of the CD2 gene to 1p13 was confirmed by in situ hybridisation.

Type

Journal article

Journal

Hum Genet

Publication Date

06/1987

Volume

76

Pages

191 - 195

Keywords

Animals, Antigens, Differentiation, T-Lymphocyte, Antigens, Surface, Chromosome Banding, Chromosome Mapping, Chromosomes, Human, Pair 1, DNA, Humans, Hybrid Cells, Karyotyping, Mice, Nucleic Acid Hybridization, Rats, T-Lymphocytes