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Polymerized flagellin and E. coli lipopolysaccharide both express adjuvanticity in vivo and in vitro for responses to hapten conjugated to sheep erythrocytes, and hapten conjugated to soluble thymus-dependent antigens. In the case of erythrocyte-bound hapten, adjuvanticity is expressed in the absence of thymus-derived cells (T cells). However, in the case of responses to soluble thymus-dependent conjugates, carrier-specific T cells would appear to be necessary for adjuvanticity to be expressed. On the basis of these observations an hypothesis for the mechanism of B-cell induction and tolerance is proposed.


Journal article



Publication Date





509 - 522


Adjuvants, Immunologic, Animals, Antibody Specificity, Antigen-Antibody Reactions, Antigens, Bacterial, B-Lymphocytes, Carrier Proteins, Erythrocytes, Escherichia coli, Flagella, Haptens, Mice, Models, Biological, Rabbits, Sheep, Solubility, T-Lymphocytes