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Antibodies to SOXB1 proteins in patients with paraneoplastic disorders are associated with small-cell lung cancer (SCLC), particularly in Lambert-Eaton myasthenic syndrome (LEMS). We aimed to establish if SOX2 antibodies could be used to identify SCLC and other tumours found in a range of paraneoplastic disorders and controls. SOX2 antibodies were detectable in 61% of patients with LEMS-SCLC, and in other paraneoplastic disorders, such as opsoclonus-myoclonus and paraneoplastic cerebellar degeneration, only when there was an underlying SCLC. SOX2 antibodies are specific (>90%) markers for SCLC, but are rarely found in patients with other tumours, whether neurological symptoms are present or not.

Original publication

DOI

10.1016/j.jneuroim.2018.11.003

Type

Journal article

Journal

J Neuroimmunol

Publication Date

15/01/2019

Volume

326

Pages

14 - 18

Keywords

Antibodies, Lambert-Eaton myasthenic syndrome, Paraneoplastic, SOX2, Small-cell lung cancer