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Recent work has shown that a major population of murine influenza A specific cytotoxic T lymphocytes (CTL) recognize the viral nucleoprotein. In order to investigate the mechanism by which this nonglycoprotein component of the virus is recognized by CTL, a series of deletion mutants of an A virus NP gene were studied. The results showed that CTL recognize three distinct epitopes of the NP molecule. Both N- and C-terminal fragments of the protein are transported, independently of each other, to the site of recognition by CTL. These findings imply that a mechanism may exist for transport to the cell surface and presentation to CTL, of viral proteins and protein fragments that lack defined signal sequences.


Journal article



Publication Date





457 - 467


Animals, Antigens, Viral, Clone Cells, Epitopes, Genes, Viral, H-2 Antigens, Influenza A virus, L Cells (Cell Line), Mice, Mice, Inbred C57BL, Mice, Inbred CBA, Mutation, Nucleoproteins, Recombination, Genetic, T-Lymphocytes, Cytotoxic, Transcription, Genetic, Transfection, Viral Proteins