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Tg epsilon 26 mice display an arrest very early in T cell development that has a profound effect on the architecture of thymic stromal cells. We have recently demonstrated that transplantation of wild-type bone marrow cells restores the thymic microenvironment of fetal but not adult Tg epsilon 26 mice. Here, we report that T cell-reconstituted adult Tg epsilon 26 mice develop a spontaneous wasting syndrome characterized by extensive inflammation of the colon, resembling human ulcerative colitis. Colitis in these animals was marked by substantial infiltration of the colon by activated thymus-derived CD4+ T cells. Importantly, bone marrow-transplanted Tg epsilon 26 mice previously engrafted with a fetal Tg epsilon 26 thymus did not develop colitis. These results suggest that T cells selected in an aberrant thymic microenvironment contain a population of cells able to induce severe colitis that can be prevented by T cells that have undergone normal thymic development.

Type

Journal article

Journal

Immunity

Publication Date

07/1995

Volume

3

Pages

27 - 38

Keywords

Animals, Bone Marrow, Bone Marrow Transplantation, CD8 Antigens, Cell Differentiation, Colitis, Ulcerative, Immunophenotyping, Mice, Mice, Inbred CBA, Mice, Transgenic, T-Lymphocytes, Thymus Gland