Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

To evaluate the spectrum and regulation of matrix metalloproteinases (MMPs) in bacterial meningitis (BM), concentrations of MMP-2, MMP-3, MMP-8, and MMP-9 and endogenous inhibitors of metalloproteinases (TIMP-1 and TIMP-2) were measured in the cerebrospinal fluid (CSF) of 27 children with BM. MMP-8 and MMP-9 were detected in 91% and 97%, respectively, of CSF specimens from patients but were not detected in control patients. CSF levels of MMP-9 were higher (P<.05) in 5 patients who developed hearing impairment or secondary epilepsy than in those who recovered without neurological deficits. Levels of MMP-9 correlated with concentrations of TIMP-1 (P<.001) and tumor necrosis factor-alpha (P=.03). Repeated lumbar punctures showed that levels of MMP-8 and MMP-9 were regulated independently and did not correlate with the CSF cell count. Therefore, MMPs may derive not only from granulocytes infiltrating the CSF space but also from parenchymal cells of the meninges and brain. High concentrations of MMP-9 are a risk factor for the development of postmeningitidal neurological sequelae.

Original publication

DOI

10.1086/313922

Type

Journal article

Journal

Clin Infect Dis

Publication Date

07/2000

Volume

31

Pages

80 - 84

Keywords

Blood-Brain Barrier, Brain Damage, Chronic, Child, Child, Preschool, Follow-Up Studies, Haemophilus Infections, Haemophilus influenzae, Humans, Infant, Matrix Metalloproteinase 2, Matrix Metalloproteinase 3, Matrix Metalloproteinase 8, Matrix Metalloproteinase 9, Meningitis, Bacterial, Meningitis, Meningococcal, Meningitis, Pneumococcal, Neisseria meningitidis, Retrospective Studies, Spinal Puncture, Streptococcus pneumoniae, Time Factors, Tissue Inhibitor of Metalloproteinase-1, Tissue Inhibitor of Metalloproteinase-2, Tumor Necrosis Factor-alpha