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Guanarito virus (GTOV) is an emergent and deadly pathogen. We present the crystal structure of the glycosylated GTOV fusion glycoprotein to 4.1-Å resolution in the postfusion conformation. Our structure reveals a classical six-helix bundle and presents direct verification that New World arenaviruses exhibit class I viral membrane fusion machinery. The structure provides visualization of an N-linked glycocalyx coat, and consideration of glycan dynamics reveals extensive coverage of the underlying protein surface, following virus-host membrane fusion.

Original publication




Journal article


J Virol

Publication Date





13070 - 13075


Amino Acid Sequence, Arenaviruses, New World, Cell Line, Crystallography, X-Ray, Glycosylation, Hemorrhagic Fever, American, Humans, Models, Molecular, Molecular Sequence Data, Protein Structure, Secondary, Sequence Alignment, Viral Fusion Proteins, Virus Internalization